What Is THCp?
THCp (tetrahydrocannabiphorol) is a naturally occurring phytocannabinoid found in the cannabis plant, specifically within cannabis sativa. As one of the latest cannabinoids found in cannabis, THCp was first identified in 2019 by a team of Italian researchers, sparking excitement due to its unique chemical structure and potency compared to traditional THC.
While cannabis contains many compounds, including the famous tetrahydrocannabinolic acid (THCa) and cannabidiol (CBD), THCp stands out as a newly discovered cannabinoid with very low concentrations naturally present in cannabis plants. Its discovery adds to the growing list of hemp derived cannabinoids and expands our understanding of how these compounds interact with the human body.
Chemical Structure and Binding Affinity
The distinctiveness of THCp lies in its structural compound, particularly its longer alkyl side chain. Unlike traditional THC, which has a pentyl side chain of five carbon atoms, THCp features a heptyl side chain consisting of seven carbon atoms. This difference plays a key role in its interaction with cannabinoid receptors.
Research indicates that THCp binds with a much higher affinity to CB1 receptors—those found abundantly in the brain and central nervous system—compared to THC the compound responsible for cannabis’s typical psychoactive effects. In fact, studies suggest that THCp may exhibit in vivo cannabimimetic activity higher than THC, potentially making it up to 30 times more potent in terms of receptor binding.
How THCp Interacts with the Body
Like other cannabinoids, THCp interacts with the body through the endocannabinoid system, specifically by binding to CB1 receptors throughout the body. This binding causes various psychoactive effects, similar to but often stronger than those produced by traditional THC.
The longer alkyl side chain allows THCp to bind more securely to receptors, resulting in a pronounced impact on mood, pain perception, and other physiological processes regulated by the endocannabinoid system. These enhanced effects have caused a particular stir in the cannabis industry, raising interest in the potential uses and benefits of this cannabinoid.
Potential Benefits and Uses
Although research is still in early stages, researchers found evidence suggesting that THCp may offer promising therapeutic applications, such as:
- Pain relief to patients suffering from chronic or severe pain.
- Potential mood enhancement effects, helping alleviate anxiety and depression.
- Possible benefits in managing nausea and appetite stimulation.
The evidence suggesting that THCp may be more potent than THC opens the door for new medicinal approaches, possibly allowing effective results at smaller doses.
Differences Between THC and THCp
While both THC and THCp are related closely, their differing chemical structures and binding affinities lead to distinct experiences:
- THC has a side chain with five carbon atoms.
- THCp has seven carbon atoms in its side chain, leading to higher affinity for cannabinoid receptors.
This means THCp binds to CB1 receptors more effectively, causing stronger psychoactive effects, even at lower quantities compared to traditional THC.
Methods of Consumption
THCp can be consumed through various methods, many similar to traditional cannabinoids:
- Vaping: Allows fast absorption and quick onset of effects.
- Edibles: Provide longer-lasting effects but slower to kick in.
- Tinctures: Enable precise dosing and fast sublingual absorption.
- Topicals: Target localized relief without systemic psychoactive effects.
As with other cannabinoids, method choice affects the intensity and duration of effects.
Risks and Side Effects
While THCp is a naturally occurring cannabinoid and often considered THCp safe when used responsibly, there are potential risks and side effects to be aware of:
- Increased anxiety or paranoia, especially in sensitive individuals.
- Dry mouth, dizziness, or lethargy.
- Potency means users should start with low doses to avoid overwhelming effects.
Individual reactions vary due to the uniqueness of each person’s endocannabinoid system and factors such as metabolism and tolerance.
Legal Status of THCp
Under the 2018 Farm Bill, THCp legal status in the U.S. generally falls under hemp derived cannabinoids rules if products contain less than 0.3% Delta 9 THC. However, state laws vary widely, with some states regulating THCp similarly to THC due to its potent psychoactive effects.
Consumers should be mindful of local regulations and keep informed as the legal landscape around this newly discovered cannabinoid continues to evolve.
THCp and Drug Testing
Most standard drug tests do not specifically screen for THCp, but because it binds to CB1 receptors and shares chemical similarities with THC, THCp may show up on a drug test if metabolized into THC or related compounds.
If you have a medical marijuana card or are subject to drug testing, consult professionals and exercise caution regarding consumption.
Current Research and Future Outlook
The discovery of THCp by Italian researchers has sparked ongoing research into its vivo cannabimimetic activity and therapeutic potential. As studies continue, experts hope to clarify its safety profile, dosage guidelines, and specific benefits.
With cannabis sativa L continuing to reveal potentially awaiting discovery cannabinoids, THCp represents a promising frontier in both medical marijuana and recreational cannabis markets.
Conclusion
THCp is a powerful and intriguing phytocannabinoid found in cannabis, notable for its stronger binding to cannabinoid receptors compared to traditional THC. While it may offer enhanced psychoactive effects and therapeutic potential, caution is advised due to its potency.
Staying informed about THCp legal status, risks and side effects, and consumption methods will help users safely explore this exciting new cannabinoid as more research unfolds.